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Once steady state is reached, the plasma concentrations will fluctuate between a constant peak ( C ss,max ) and a constant trough ( C ss,min ) with each dosing interval, as long as the dose and interval remain unchanged

Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury

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Oncogenesis 2019, 8 (3), 112

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And the modulatory rather than stimulatory nature of its effects on systems like nitric oxide and inflammation suggests a lower risk of overcorrection compared to directionally-acting compounds