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These results were in line with a C57BL/6 J APP/PS1 transgenic mouse model, in which vitamin A deprivation leads to an increase in the cortex of pTau in addition to an increase in A40 and A42 in the cortex and in the expression of -site amyloid precursor protein-cleaving enzyme 1 (BACE1) gene transcript (27)

Autonomous dysregulation can also account for some of the perceived or objective disturbances seen by those patients [18]

Conversely, PLCAR was found to be significantly more effective for alleviating general, physical fatigue and muscular weakness (p = 0.004)

doi: 10.5653/cerm.2019.03440

**These statements have not been evaluated by the Food and Drug Administration

doi: 10.1111/febs.16059 23 YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVS