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Approximately 80% of TP53 mutations are missense mutations occurring within the central sequence-specific DNA binding domain, which is clustered around a few hotspot amino acid residues

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen-induced liver injury

[DOI] [PubMed] [Google Scholar] 147.Towsend K., Trevino V., Falciani F., Stewart P.M., Hewison M., Campbell M.J

doi: 10.1093/molehr/gap024 96 FuGDaiJLiZChenFLiuLYiLet al

10.3748/wjg.v12.i38.6098 14 FeiliX.WuS.YeW.TuJ.LouL

p53 upregulates the damage-regulated autophagy modulator 1 ( DRAM1 ), which codes for a lysosomal protein that is required for the induction of autophagy [80]
