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The randomized, double-blind, placebo-controlled study tested various doses of Danuglipron against a placebo over 16 weeks
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On the other hand, lactate produced by glycolysis inhibits RLR signaling by direct binding to MAVS (47)
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Yang et al (122) found that Aldh2 deficiency induced NOX2-dependent NETosis through the endoplasmic reticulum stress/GST2/LTC4 pathway and the LTC4 receptor antagonist montelukast might be a potential therapeutic option
CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism
