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Research has shown that IL-4-STAT6 signaling, through direct transcriptional regulation of inflammatory enhancers, reduces the sensitivity of macrophages to endogenous signals associated with pathogens, stress, and injury (Valle and Lecarpentier, 2016)

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Journal of Physiology-Paris, 91 (3-5), 173-178

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Furthermore, IGF-1 activates the PI3K/Akt/FoxO1 pathway without affecting TLR2/4 expression in an in vitro hyperglycemic study [142]

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