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When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1g/ml) for 10minutes, 1h, and 24h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan

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RELEVANCE: Older adults are at higher risk of frailty, sarcopenia, dehydration, and nutritional decline

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Triple receptor agonist: GLP-3R, also identified in scientific literature as LY-3437943, is an investigational peptide classified as a triple-receptor agonist