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Cytoskeletal contraction and collapse: Abnormal cross-linking of the actin network causes cytoskeletal contraction and detachment from the plasma membrane, ultimately disrupting cellular morphology and structural integrity, triggering rapid cell death

Phenytoin is primarily metabolized by the hepatic cytochrome P450 enzyme CYP2C9 and to a lesser extent by CYP2C19 and is particularly susceptible to inhibitory drug interactions because it is subject to saturable metabolism

HCG side effects may include headache, fatigue, and mood changes

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Our mitochondriathe cells energy production centersare dependent on glutathione, which can cross mitochondrial membranes and minimize reactive oxygen species (ROS) buildup

Bhatia SN, Ingber DE (2014) Microfluidic organs-on-chips