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There are two main risk factors for B12 deficiency - pernicious anaemia and diet

Clinician awareness and implementation of vitamin B12 monitoring in metformin-treated patients

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doi: 10.1016/j.nutres.2015.10.003

Children Infants (06 months): 0.4 mcg/day 712 months: 0.5 mcg/day 13 years: 0.9 mcg/day 48 years: 1.2 mcg/day 913 years: 1.8 mcg/day 1418 years: 2.4 mcg/day Vegans and vegetarians are advised to supplement with B12 as it is only present in animal foods

In this review, we will focus on the effect of metformin on the absorption of vitamin B12 and on its proposed mechanisms in hindering vitamin B12 absorption