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Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30