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Microglial NF-B activation under GSH-depleted conditions creates a pro-inflammatory loop where increased ROS promotes NF-B activation, which upregulates inflammatory cytokines and further stimulates oxidative stress (Liu et al., 2017

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5.2.1 Blocking chemotactic axes: disrupting MDSC recruitment MDSCs are recruited through GM-CSF, CXCL12, and other tumor-derived chemokines (136, 146, 147)

Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells