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Potency: In preclinical studies, Dihexa was found to be up to one million times more potent than BDNF in promoting synaptic connectivity highlighting its potential but also raising concerns about overstimulation

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J Clin Med (2020) 9

However, the authors mentioned that the presence of visible product-related particles during stability storage in any drug product requires a thorough product-specific safety assessment that, at minimum factors in the mechanism of action of the drug, the route of administration, patient population as well as the visible particle size/count

Published safety data from clinical trials report no significant adverse effects across all studied doses and durations

I often feel it wearing off about the end of day two...makes sense
