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In the hippocampus specifically, BDNF is essential for long-term potentiation (LTP), the process by which synaptic connections strengthen in response to repeated stimulation

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Melatonin not only regulates the sleep-wake cycle but also serves as a powerful antioxidant that helps reduce oxidative stress and inflammationtwo major contributors to aging and chronic disease Reiter et al., Endocrine , 2006
