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Compounded medications are only indicated for patients when a prescribing practitioner determines that the compounded preparation produces a significant difference for their patient compared to the FDA-approved product

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Cyclical changes in E2 and P4 alter hypothalamicpituitaryadrenal (HPA) axis sensitivity, modifying cortisol dynamics, stress perception, and emotional reactivity across the cycle [56]
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Once opened, handling and disposal should follow internal laboratory protocols