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Once a TLR binds to a ligand, molecular adapters, including MyD88, trigger a cascade of signaling reactions [32, 61, 73]

[DOI] [PMC free article] [PubMed] [Google Scholar] Scherlie R

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Furthermore, the balance of descending modulation from the brainstem shifts from net inhibition to net facilitation, with pathways from the RVM promoting, rather than suppressing, dorsal horn excitability
