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CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP Cascade1

doi: 10.1093/molehr/gaac018 109 PrietoLQuesadaJFCamberoOPachecoAPellicerACodoceoRet al

The elimination strategy targeting senescent cells thus represents a promising area of research in the context of various pathologies, including cancer, cardiovascular, and neurodegenerative diseases, by targeting the very biological foundation of aging

The problem was that these fragments degraded almost instantly when introduced into the bloodstream, rendering them therapeutically useless

Globally, approx

Cunningham-Rundles, S