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Discontinue use and seek emergency care if these occur
Disruption of metabolic reprogramming (e.g., glycolysis inhibition) significantly attenuates M1 polarization and alleviates inflammatory responses
10.1038/sj.bjp.0702669 74 SamuelssonB.DahlenS
Q., Agha M
From the study of new phenyl dihydrouracil (PD)-based PROTACs designed by this group, PD-PROTAC 113 (SJ43489) stands out, capable of degrading the LCK protein (DC 50 = 0.8 nM) and inhibiting the cell viability of KOPT-K1 cells with nanomolar potency (IC 50 = 37 nM) 156
But in any case, its only a temporary shift
