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Their research found that an EZH2 inhibitor, which methylates H3K27, upregulated both CD38 mRNA and protein expression in KDM6A knockout cells, and restored the sensitivity of these knockout cells to daratumumabmediated NKcell cytotoxicity in vitro and in xenograft mouse models

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These miRNAs and especially miR-223 which are involved in PI3K/AKT, IGF1, and MEK/ERK/NF-B signaling cascades could represent a molecular link between inflammation and cancer

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