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10.1016/j.freeradbiomed.2022.02.017 100 HassaneinE

We used Slow Fade Diamond Antifade Mountant for nuclear staining with DAPI (Invitrogen)
doi: 10.1186/1743-8977-10-29

148,157,158 Specifically, some cancer cells, such as PDAC and CRC cells, depend on a noncanonical glutamine metabolism pathway in the cytosol under the regulation of oncogenic KRAS activation

As a result, E3 ubiquitin ligases, which select substrates for ubiquitylation, serve as regulatory gatekeepers of myriad biological processes, including biologically critical functions such as protein homeostasis and quality control, cell cycle, and the DNA damage response (Kulathu & Komander, 2012

Importantly, Sirtuin localization can vary depending on cell type or cell cycle stage (Pande and Raisuddin 2023)
