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Research has shown that ROS generation plays a role in NLRP3 inflammasome-mediated pyroptosis, contributing to the pathogenesis of various inflammatory diseases, including heart failure (34), metabolic syndrome (34), diabetes (35), and liver fibrosis (36)

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It is now well demonstrated that, besides helping correct protein folding, chaperones can perform multiple functions such as preventing denaturation, rearranging proteins after oxidative and pH stress and performing targeted proteolysis on the irreversible denaturated proteins

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