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Chronic excessive alcohol consumption results in inflammation in multiple organs including the brain

A 2014 Cell Press article (Mason et al.) used the MDA-MB-468 model to identify CFI-400945, a polo-like kinase 4 (PLK4) inhibitor, as a candidate for clinical evaluation due to well-tolerated toxicity and inhibition of tumor growth via dysregulated mitosis and subsequent apoptosis

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Recent studies have further confirmed the pivotal role of aromatic amines and other tobacco constituents in the development of bladder cancer (Kakizoe et al., 1979)

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When reduced AP was simply incubated in air-saturated buffer for as long as 6 h, no significant activation could be seen (Figure 2)