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Eder, J

The protocol calls for 5 mg of epitalon administered subcutaneously once daily for 20 consecutive days

These miRNAs and especially miR-223 which are involved in PI3K/AKT, IGF1, and MEK/ERK/NF-B signaling cascades could represent a molecular link between inflammation and cancer

Concentrations of 10-20mg/ml work well, requiring 0.05-0.3ml injection volumes that standard insulin syringes measure accurately

Itaconate is transported to the cytosol where several enzymes of glucose metabolism are inhibited including aldolase A (encoded by the ALDOA gene), glyceraldehyde-3-phosphate dehydrogenase (encoded by the GAPDH gene), lactate dehydrogenase (encoded by the LDHA gene), enolase (encoded by the ENO1 gene), and the PKM2 isoform of pyruvate kinase (encoded by the PKM gene)