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Brain imaging studies in humans have shown that, in the striatum, D2Rs are positively associated with baseline metabolic activity (marker of brain function) in frontal cortical regions and inversely associated with the sensitivity to the rewarding effects of psychostimulant drugs (102, 341, 342), whereas preclinical studies in rodents have shown that D2R upregulation interferes with drug consumption (323, 324)

For people in water-damaged buildings, this might mean professional remediation, relocation, or significant environmental changes before symptom resolution becomes possible