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Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain

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In the last years, approaches to design future therapies consider novel aspects as, for example, heritability of GSH levels in different organs/tissues [190], regulation of epigenetic mechanisms as response to variations of glutathione level or GSH/GSSG ration [191]

Recent research at the Technical University of Munich approached this subject and achieved some positive results

These states were captured in the presence of agonist 2S, 4R-4-methyl glutamate (SYM) 26 and antagonist UBP310 27 respectively (Supplementary Fig

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