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doi: 10.2147/OTT.S298512 195 MaoLSummersWXiangSYuanLDauchyRTReynoldsAet al

ROS can harm pituitary and adrenal gland mitochondria, impairing cortisol secretion and disrupting the HPA axiss negative feedback, which boosts stress and emotional disorders

Oxidative stress drives divergent evolution of glutathione peroxidase (GPX) gene family in mammals

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Novel delivery systems may improve stability, but consistent systemic exposure remains a primary challenge

5AC) were significantly facilitated by the -KG analogue DM-KG but were suppressed by the IDH inhibitor Enasidenib, which markedly decreased -KG levels (Fig