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It is important to induce a balance between cholinergic and dopaminergic receptors in PD, as it is well established that lesions in the nigra striatum are usually observed in PD, significantly reducing dopamine concentrations in affected patients

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doi: 10.1038/cdd.2010.48 51 WanetAArnouldTNajimiMRenardP

In addition, NADH can have other effects, such as increased release of calcium ions (Ca ++ ) release from certain channels on the ER, as demonstrated in a cell line called PC12 cells (Kaplin et al