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MT-TK mutations, although rare, are linked with more severe phenotypes and rapid disease progression

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

The underlying cause of renal dysfunction, therapeutic interventions prevalent in CKD patients (e.g., antibiotics and immunotherapy), CKD-specific treatment interventions such as iron supplementation and phosphate binders (Dostal et al., 2015), and dietary restrictions (Wong et al., 2014) have all been linked to these shift patterns

Additionally, TMAO induced hypertension by accelerating vascular endothelial dysfunction (124)

doi: 10.1038/ajg.2010.10

Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure