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Leg ulcers in cirrhosis patients result from necrotic tissue due to hypoxia and venous reflux obstruction, with similar occurrences in chronic venous insufficiency and diabetes (89, 90)

E2 deficiency during perimenopause is a major driver of mitochondrial bioenergetic impairment, with the ETC being a primary target

Total protein levels were normalized to -actin (ACTB), and nuclear protein levels were normalized to Lamin B1

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Once, inside the cell, selenomethionine directly participates in protein synthesis or get metabolised to release selenocysteine which can be further catabolised to selenide

(2) feedback inhibitory effects of GSH on glutamate cysteine ligase (GCL) activity (the first biosynthetic enzyme), which is regulated by the availability of cysteine (Jones, 2017)