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In biochemical and preclinical research systems, GLP-RT interacts with three class B G protein-coupled receptors that regulate metabolic signaling networks: GLP-1R, GIPR, and GCGR

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Other adverse effects, including depression, sleep disturbances, and anxiety, have also been noted.While these side effects are usually transient, they can be bothersome enough to prompt some patients to discontinue treatment prematurely

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