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Ishii T, Matsuse T, Teramoto S, Matsui H, Miyao M, Hosoi T, et al

Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during withanolide D-induced apoptosis

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R., Peiser, C., Groneberg, D

No evidence of tolerance development (requiring progressively higher doses to achieve the same effect) or physical dependence (withdrawal symptoms upon discontinuation) has been documented in available research, distinguishing DSIP favorably from traditional sleep medications that commonly cause both tolerance and dependence