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Specifically, resveratrol regulates the JAML/SIRT1 lipid synthesis pathway through elevating the SIRT1 expression to reduce the expressions of SREBP-1 and ChREBP protein, further mitigating lipid deposition mediated by SREBP-1 and ChREBP, improving renal pathology and renal function in DKD patients and HFD-induced DKD mice (Gu et al., 2022)

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