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The possible explanation for the observed associations might be in the fact that, similarly to GST theta class, alpha class also participates in bioactivation of several drugs and certain neurotoxic compounds 51

For patients with type 2 diabetes or obesity, tirzepatide represents a well-studied, FDA-approved medication with demonstrated efficacy in clinical trials

Elevation in serum leptin level was also observed in these GFAT overexpressing mice

successfully prepared siRNA for respirable TNF- using a thin-film freeze-drying method and encapsulated it in SLN for delivery to the lungs to silence TNF- gene expression in cells (Wang et al., 2020)

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Using a combination of transcriptomics, metabolomics, and gnotobiotic models, we demonstrate that REcN-F/Ca shows superior ability in restoring glucose homeostasis, attenuating adipose inflammation, and enriching butyrate-producing taxa ( Blautia and Lachnospiraceae)
