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Inhibition of the Trx system by auranofin induced cell death (most likely ferroptosis) only in non-endocrine small cell lung cancer, whereas inhibition of the Grx system by buthionine sulfoximine killed specifically the endocrine cells [203]

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Ferroptosis has recently been identified as a new form of regulated necrosis, which is characterized by iron-dependent lipid peroxidation, irreparable lipid damage, membrane disruption, and necrotic cell death 9, 10