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2 Treatment for type 2 diabetes is initiated based on (glycated hemoglobin) HbA1C levels, treatment goals, and cardiovascular, renal, as well as hypoglycemia risk

Anorexigenic signaling through TRH and CRH induces anorexia and thermogenesis

During inflammatory processes, triglycerides undergo hydrolysis, forming free fatty acids (FFA) (Zhu et al., 2022), which are toxic to hepatocytes and induce apoptosis through both extrinsic and intrinsic pathways ( (2) Toxic Lipid Metabolites: The metabolism of lipids produces toxic metabolites such as malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and malondialdehyde-acetaldehyde adducts (MAA), which further damage mitochondria and promote free radical production (Schaffert, 2009)

- Avoid: Redundant mechanisms, antagonistic effects, or compounded cardiovascular/GI risk

Protocol B (Injectable + topical): 1

doi: 10.1136/bmj.322.7302.1571