glutathione inhibitor cancer Overcoming resistance to cisplatin by inhibition of S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo Glutathione Synthesis in Cancer Cells

Moreover, the intravenous anesthetic propofol, which acts on the nervous system, has been shown to reduce the resistance of NSCLC cells to cisplatin by upregulating the levels of miR-744-5p and miR-615-3p while downregulating GPX4 expression [121]

Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-kappaB/HIF-1 pathway

Journal of Functional Foods 67:103827

Ex vivo studies demonstrate that berberine and its eight analogs inhibit cancer cell viability in a canine mammary carcinoma cell line and transgenic zebrafish models through apoptosis induction, while zebrafish embryo toxicity experiments are conducted to assess the in vivo safety of berberine [198, 199]

investigated flap- and graft-based interventions

This is justified in the great majority of cases