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This underscores that Th2-eosinophilic inflammation in UC might be especially steroid-responsive, and periostin or IL-5/IL-13 levels could serve as biomarkers to predict therapy response

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Due to their high plasticity, M1 and M2 macrophages are interconvertible in response to changes in the TME or therapeutic interventions 18

doi: 10.1016/S0006-8993(02)02551-9

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Furthermore, these trials have limitations, including small sample sizes, wide age ranges of participants, short treatment durations, and heterogeneity in patient treatment (162)