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RCT conducted in patients with T2D showed that high doses of tirzepatide represent the most efficacious incretin-based anti-diabetes drug in terms of BW reduction 33 , sustaining the development of the SURMOUNT program to explore its efficacy and safety in the management of obesity 9

G ene sequence analyses At the C-terminus of the enniatin synthetase (Esyn) gene cluster two PCP domains are located, one catalyzing ester bonds and thereby performing peptide elongation and cyclisation and another one acting as a waiting position 23,24

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