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Introduction Reactive oxygen species (ROS) in plants including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals (OH), and singlet oxygen ( 1 O 2 ), are reactive byproducts of oxygen metabolism [1,2]

Plants lacking tocopherols exhibit greater lipid oxidation during seed desiccation and quiescence, poor seed germination, and substantially shorter roots at maturity (Mene-Saffrane et al

Acta Pharmaceutica Sinica

[DOI] [PubMed] [Google Scholar] 200.Kendler B.S

Activation of these sensors triggers PI3K/Akt signaling and eNOS activation, increasing NO production as well as promotion of nuclear factor erythroid 2-like 2 (Nrf2), responsible for antioxidant gene expression [206]

Although our collective findings pointed at excess oxidative stress in the cytosol of parkin-deficient brain (herein), these unbiased proteomic screens had previously identified dysregulated cytosolic as well as mitochondrial enzymes without apparent difference in mitochondrial structures (or numbers) within neurons of the nigrostriatal pathway [22, 36]