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Levodopa remains the most effective agent for controlling motor symptoms, but its long-term use leads to motor complications, reduced efficacy, and treatment resistance (Kulisevsky, 2022

Olanow CW (2004) The scientific basis for the current treatment of Parkinsons disease

Simultaneous blockade of the HMGB1TLR4 axis (e.g., via neutralizing antibodies) and the NLRP3 inflammasome (e.g., using MCC950) can decrease the secretion of IL1 in experimental sepsis models

Furthermore, it has been shown in other studies that the protective effects against cerebral ischemia-reperfusion injury, achieved by inhibiting ferroptosis, are partially diminished upon induction by RSL3 (125,132)

A member of the CTRP family, C1q/TNF -related protein 6 (CTRP6), has been shown to reduce CTRP6 expression in the plasma of heart failure patients