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We treated hepatocytes with auranofin, which inhibits redox-active selenoproteins, including thioredoxin reductases and, at the dose used here, glutathione peroxidases 1, 2, 3, 4, and 6 (Chaudiere and Tappel, 1984, Roberts and Shaw, 1998, Scarbrough et al., 2012)

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A systematic dissection of its core components and biological functions could not only deepen our understanding of how Mtb leverages metabolic adaptations to counteract host defense mechanisms but also provide critical insights for developing novel anti-tubercular therapies targeting metabolic vulnerabilities

Shi J, Xu J, Chen YE, Li JS, Cui Y, Shen L, Li JJ, Li W

5 Targeting gut microbiota for acute liver injury Various factors, such as drugs, toxicants, and viral infections, produce hepatotoxicity and lead to ALI, which severely damages liver function and inevitably damages human health (76)

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