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doi: 10.1371/journal.pone.0098367 [DOI] [PMC free article] [PubMed] [Google Scholar] 115

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For instance, while we propose that the glutathione metabolite 5-oxoproline may promote tumorigenesis by reducing the proportion of CD28 - CD25 ++ CD8 + T cells, it is necessary to confirm through animal models or in vitro co-culture experiments whether treatment with 5-oxoproline or modulation of glutathione metabolism can directly impair T cell function and accelerate tumor formation

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