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Membrane fluidity alteration may thus contribute to pore-induced DMSO influx into the cytoplasm and reactive oxygen species production, leading to greater cytotoxicity in HUVECs, which have low antioxidant capacity

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First, sustained hyperglycemia and metabolic disturbances activate TGF-/Smad signaling, which stimulates excessive extracellular matrix (ECM) deposition (collagen I/IV, fibronectin) by mesangial cells and fibroblasts while simultaneously inhibiting matrix degradation through upregulation of plasminogen activator inhibitor-1 (PAI-1)

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Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes

Western blot Proteins were extracted from cells and tissues using RIPA lysate containing protease inhibitors and phosphatase inhibitors