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[36] [37] [38] A long-term study where vitamin B 12 was supplemented across a period of 10 years, led to lower levels of weight gain in overweight or obese individuals (p 20% of elderly individuals showed evidence of marginal vitamin B 12 depletion (serum vitamin B 12 : 148221 pmol/L)

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Relationship to the GH-IGF-1 Axis Because this fragment does not appear to stimulate IGF-1 production in laboratory models, it provides researchers with a tool to study the IGF-1-independent aspects of GH signalling in metabolic biology

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