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Under hypoxic conditions, knockout of the HIF-1 gene inhibits uninterrupted hypoxia-induced radioresistance while increasing the overall radiosensitivity of the tumor (Hsieh et al., 2010)

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Previously, the CCAAT-binding complex has been shown to be involved in oxidative stress response 31

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Future studies should investigate the establishment of biomarkers of durable tolerance induction and optimization criteria for dose regimens, as well as combinations with existing biologics or small molecules