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[DOI] [PubMed] [Google Scholar] 115.Cruz F, Scott SR, Barroso I, Santisteban P, Cerdan S

By binding to CD80 and CD86 receptors on APC and obstructing the costimulatory effects of the T cell surface molecule CD28, activation of CD8 + T cells and the release of inflammatory cytokines linked to AA, namely IL2, TNF, and IFN, are both efficiently inhibited by abatacept [226]

Most gastrointestinal side effects resolve by week 12, leaving minimal symptoms during months 4-11

These include cold and flu symptoms, signs of hypoglycemia, abdominal pain, nausea, vomiting, constipation, diarrhea, fatigue and allergic and adverse reactions

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SPG302 reverses synaptic and cognitive deficits without altering amyloid or tau pathology in a transgenic model of Alzheimers disease