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This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]

Chang, H

10.1016/j.neuron.2014.01.013 118 FreischmidtA.WielandT.RichterB.RufW.SchaefferV.MullerK.et al

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Mice were treated with doxycycline for two weeks