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A better understanding of the detailed interactions between the factors involved will contribute to further elucidate the cell defense capability, which is impaired in neurodegenerative diseases such as ALS [67, 141, 170], and may reveal the path for identifying novel potential therapeutic targets

Models of ASD show behavioral and biological phenotypes that differ based on the spatiotemporal targeting of the gene ( Fmr1 KO mice after 3 weeks of age (Tang et al., 2015), and both Shank3 and Syngap1 show changes in interaction partners throughout development (Li et al., 2016, 2017)

PMID 14616064

Riboflavin B2: Hypothyroidism induces the symptoms of riboflavin deficiency

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