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The mechanism (improved muscle glucose uptake plus AMPK activation) shifts how the body partitions calories, often producing visible body composition changes by week 8 to 12

Met activation is known to trigger a downstream signalling cascade involving phosphorylation of signature proteins (Fig

Other pharmacological options include catechol-O-methyltransferase (COMT) inhibitors like entacapone and opicapone, which extend the half-life of levodopa, do not cross the BBB at all and primarily affect peripheral metabolism, providing no direct action in the brain 59

Addressing these obstacles requires collaborative efforts among researchers, clinicians, regulatory bodies, and industry stakeholders