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Low-level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus

When the finely-tuned trafficking of macromolecules is dysregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune disorders can occur.[105] There is growing evidence that increased intestinal permeability plays a pathogenic role in various autoimmune diseases

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It is nearly absent, however, from the hepatocytes and cardiac myocytes [7]