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Basic Res Cardiol 116(1):21 2021 PMC7985055 *Luttrell SM, Smith AST, Mack DL

When a diet consists mainly of seafood, including shellfish, seaweed, kelp, and saltwater fish that contain TMA or TMAO [7], the lower gastrointestinal tract, or gut, harbours bacteria that convert TMAO to TMA [8]

Ethics declarations Conflict of interest DM, CdA, FG, MM, GG, MP, MC, NV, CP, CS, RSA and AC have no conflicts of interest to declare that are relevant to the content of this article

Disease severity was associated with lower caproic acid and isocaproic acid levels

There was no evidence for a worsened outcome (reduced cell survival, Figure 1), worsened infarct size (Figure 3), or in the assessment of mitochondrial energy production with metabolic challenges (Figure 4)

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes