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These results thus indicate that periodontitis drives BM neutrophil polarization towards a proinflammatory N1 phenotype at the transcriptional, phenotypic, and functional levels
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AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity

doi: 10.1021/ol9022408
However, PTX also has several toxic effects on normal cells, such as the induction of neurotoxicity and hematotoxicity (76)

This is known as a synergistic effect
